Dr. R. Guy Reeves

 
 

Publications



Contact

Email:reeves [at] evolbio.mpg.de


SKYPE (work) DrGuyReeves


Address Max-Planck-Institut für Evolutionsbiologie

Abteilung Evolutionsgenetik

August-Thienemannstrasse 2

24306 Plön (Germany)


Phone (office) 

+49 4522 763  297


 

My current research interests are focused on these main areas:

New:- Three new paper published  in the last few weeks


  1. 1.Boëte C, Agusto F, Reeves RG: Impact of Mating Behaviour on the Success of Malaria Control through a Single Inundative Release of Transgenic Mosquitoes. J Theor Biol 2014:1–11.

  2. 2.Reeves RG, Bryk J, Altrock PM, Denton J a., Reed FA: First Steps towards Underdominant Genetic Transformation of Insect Populations. PLoS One 2014, 9:e97557.

  3. 3. Gokhale C, Reeves RG, Reed FA: Dynamics of a combined Medea-Underdominant Population Transformation System. BMC Evol Biol 2014.


Also see recent columns for MalariaWorld along with Dr Rasha Azrag


IPCC, malaria and climate change: neither scaremongering or ignorant

Scientific standards and the release of genetically modified insects for vector control

Development of a  proof principle system for underdominant population transformation.


The utilisation of genetic underdominance to control insect pest populations is not a new one and was first successfully applied in the 1940s to eliminate tsetse flies ( which spread sleeping sickness) from a 25Km2 area of Tanzania . 

A transgenic construct which we call {U}, that  also exploits underdominance to push novel genes into experimental populations..  This could one day be useful to push genes into wild populations to stop particular insects species spreading diseases.

The {U} construct has the following desirable properties:

1    Geographically self-limiting; restricting itself to targeted populations of a specific                                                 species.

2    Reversible, population transformation is realistically reversible.

3    Species specific; Horizontal transfer to non-target species is highly unlikely.


This work is still at a very early stage and it will take years of multi-disciplinary work before it will be possible to determine if this approach is effective and safe.


Relevant publications

Reeves RG, Bryk J, Altrock PM, Denton J a., Reed FA: First steps towards underdominant genetic transformation of insect populations. PLoS One 2014.

International patent: PCT/EP2013/077856(see MOU about limits to commercialization)


Gokhale C, Reeves RG, Reed FA: Dynamics of a combined Medea-Underdominant Population Transformation System. BMC Evol Biol 2014.

Altrock PM, Traulsen A, Reeves RG, Reed F a (2010) Using underdominance to bi-stably transform local populations. Journal of theoretical biology 267: 62-75. doi:10.1016/j.jtbi.2010.08.004

 

Promoting public engagement in trials of  genetically  modified (GM)  insects.


If GM insect technologies can be shown to be safe and effective they have the potential to make a real contribution to controlling diseases spread by insects which cause enormous human hardship. They also have the potential to control insect damage to crop in species-specific manner without the need for the use of chemicals.

However, these technologies have an obvious potential to cause public unease.

Like many other scientists and NGOs I am actively promoting informed scientific debate about this topic. 

In Progress: Analysis of large scale global survey of expert scientists attitudes to innovative biotechnological approaches to insect control.


R. Guy Reeves, Jai A. Denton, Fiammetta Santucci, Jarosław Bryk, Floyd A. Reed

Scientific Standards and the Regulation of Genetically Modified Insects.

(2012). PLoS Neglected Tropical Diseases 6 (1) .

http://www.plosntds.org/article/info:doi/10.1371/journal.pntd.0001502

link to extended press release


Guest Editorial: Scientific standards and the release of genetically modified insects for vector control [http://www.malariaworld.org/blog/guest-editorial-scientific-standards-and-release-genetically-modified-insects-vector-control]


The Genetic Jungle - the use of genetically modified insects in conservation. Genewatch Mag (USA), Council Responsible Genetics 2012, 25:12–13.



 

Development of automated high-throughput phenotyping systems and their integration with data-management databases.


I am currently developing tools for  the management of large scale genetic projects. 

My current project has the phenotyped >50,000 Drosophila flies over the last two months.