Room: 501
Phone: 0049 431 880 6364
E-mail: mmoeller@bot.uni-kiel.de
Twitter: @MareikeMM
Research Interests
My project focuses on genome and chromosome stability of the plant pathogen Zymoseptoria tritici. The fungus has a highly dynamic genome and a very interesting feature is the presence of two different types of chromosomes, core and accessory chromosomes. These two types of chromosomes differ in several ways, including their chromatin structure. I want to investigate whether the stability of chromosomes is correlated to their chromatin structure. Therefore, I study two histone-methyltransferases involved in heterochromatin formation and their impact on genome and chromosome stability. Combined with in vitro evolution experiments I analyze how histone methylation affects the two different types of chromosomes in terms of stability and transcriptional regulation.
CV
2018-Present: PostDoc in Eva Stukenbrock’s group at the Christian-Albrechts University Kiel, Germany
2014 – 2018: PhD student in Eva Stukenbrock’s group at the Christian-Albrechts University Kiel, Germany
02/2014 – 04/2014: Visiting scholar in Michael Freitag’s group at Oregon State University, USA
2009 -2014: B.Sc. in Biology & M.Sc. in Molecular and Cellular Biology, Philipps University Marburg, Germany
Publications
Destabilization of chromosome structure by histone H3 lysine 27 methylation. Möller M, Schotanus K, Soyer J, Haueisen J, Happ K, Stralucke M, Happel P, Smith KM, Conolly LR, Freitag M, Stukenbrock EH. 2019. PLoS Genetics 15(4): e1008093. doi:10.1371/journal.pgen.1008093.
Highly flexible infection programs in a fungal plant pathogen. Haueisen J, Möller M, Eschenbrenner CJ, Grandaubert J, Seybold H, Adamiak H, Stukenbrock EH. 2018. Evolution and Ecology. 1–20. doi:10.1002/ece3.4724.
Extraordinary Genome Instability and Widespread Chromosome Rearrangements During Vegetative Growth. (2018) M. Möller, M. Habig, M. Freitag, and E. H. Stukenbrock Genetics 2, 517-529.
Evolution and genome architecture in fungal plant pathogens. Möller, M., and Stukenbrock, E.H. (2017). Nature Reviews Microbiology
Chromatin analyses of Zymoseptoria tritici: Methods for chromatin immunoprecipitation followed by high-throughput sequencing (ChIP-seq). Soyer, J.L., Möller, M., Schotanus, Connolly L.R., Galazka, J.M., Freitag, M., and Stukenbrock, E.H. (2015). Fungal Genet. Biol. 79, 63-70